Avalide (hydrochlorothiazide/irbesartan) Coupons, Discounts & Cost
Avalide is an antihypertensive drug containing irbesartan and hydrochlorothiazide (thiazide diuretic agent). One way to save money on the Avalide (hydrochlorothiazide/irbesartan) retail cost regardless of income and insurance status is to use Avalide (hydrochlorothiazide/irbesartan) coupons or discount cards from RXCoupons. Use our Avalide (hydrochlorothiazide/irbesartan) coupons at your online pharmacy and receive up to 75% off the sale price each time you refill your prescription.
What is Avalide (hydrochlorothiazide/irbesartan)?
Avalide is an antihypertensive drug containing irbesartan and hydrochlorothiazide (thiazide diuretic agent). The combination of these ingredients helps reduce blood pressure.
After oral administration, the drug will reach a peak level in about 4 hours. The effects of Avalide can last 6 to 12 hours. High blood pressure will be reduced with the first few doses of the drug. The maximum effect is observed after 6-8 weeks of treatment. Long-term Avalide therapy helps maintain optimal health in patients with high blood pressure.
Contraindications for Avalide (hydrochlorothiazide/irbesartan)
The drug should be avoided during II and III trimester of pregnancy and lactation. It is contraindicated in case of hypersensitivity to irbesartan and hydrochlorothiazide (or other sulfonamide medications).
The following contraindications are associated with hydrochlorothiazide: severe renal insufficiency, hypokalemia, hypercalcemia, severe hepatic impairment, biliary cirrhosis, cholestasis.
Avalide (hydrochlorothiazide/irbesartan) dosage and administration
Avalide can be used once a day with food or before meals. Daily doses higher than 300 mg of irbesartan and 25 mg of hydrochlorothiazide are not recommended.
Hydrochlorothiazide is not recommended for patients with severe renal function impairment.
There is no need to adjust the dose in elderly patients.
The drug should not be used in children under 18 years.
Avalide (hydrochlorothiazide/irbesartan) side effects
The combination of irbesartan and hydrochlorothiazide may cause the following side effects:
CNS disorders: dizziness, orthostatic dizziness.
Heart disorders: hypotension, edema, syncope, tachycardia.
Gastrointestinal disorders: nausea, vomiting, diarrhea.
Musculoskeletal system: swelling of the upper and lower extremities.
Urinary system: impaired urination.
Reproductive system: sexual dysfunction.
Avalide (hydrochlorothiazide/irbesartan) special warnings and precautions
Patients with arterial hypotension: Avalide rarely causes symptomatic hypotension in patients with high blood pressure.
Renal impairment and kidney transplantation: periodic monitoring of potassium levels and uric acid in the blood is required when Avalide is used in patients with impaired renal function. There is no experience of the use of Avalide in patients after kidney transplantation. Avalide should not be used in patients with severe renal failure.
Use Avalide with caution in patients with aortic stenosis, mitral valve stenosis and hypertrophic obstructive cardiomyopathy. The drug is not recommended in people with primary aldosteronism.
Metabolic and endocrine effects: thiazide therapy may reduce glucose tolerance. Diabetic patients may need to correct the dosage of insulin or oral antidiabetic drugs. Avalide has no effect on cholesterol and triglycerides.
Some patients may experience worsening of gout or hyperuricemia during Avalide therapy.
Electrolyte imbalance: hydrochlorothiazide may lead to water and electrolyte imbalance (hypokalemia, hyponatremia, hypochloremic alkalosis). However, concurrent therapy with irbesartan may reduce hypokalemia caused by diuretics. The risk of hypokalemia is higher in patients who use corticosteroids or ACTH.
Potassium-sparing diuretics and potassium supplements should be administered with caution with Avalide.
Thiazides may reduce calcium excretion and cause a slight increase in the calcium level in your blood. Thiazides may also lead to a significant increase in urinary magnesium excretion (hypomagnesemia). In this case, Avalide therapy should be discontinued.
Hydrochlorothiazide has been reported to cause positive results in the test for doping.
Excessive decrease in blood pressure in patients with ischemic heart disease or other cardiovascular diseases could result in a myocardial infarction.
Patients should take into account that Avalide may cause dizziness and fatigue (in rare cases). Caution is recommended during driving.
Pregnancy and lactation
Avalide is contraindicated during II and III trimesters of pregnancy. If pregnancy is detected, you should stop using the drug as soon as possible.
Avalide is contraindicated during the lactation period.