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Caduet (amlodipine/atorvastatin) drug information
Caduet (amlodipine/atorvastatin) is a combined preparation for the treatment of cardiovascular diseases (hypertension/angina and dyslipidemia). Caduet is a hypotensive lipid-lowering agent.
Caduet (amlodipine/atorvastatin) mechanism of action
Amlodipine is a calcium channel blocker and atorvastatin is a hypolipidemic agent.
Amlodipine blocks the flow of calcium ions across the membranes in the smooth muscle cells of the myocardium and blood vessels. It has a direct effect on smooth muscle relaxation. Amlodipine reduces total peripheral resistance. It helps reduce the load on the heart and oxygen demand.
It was noted that amlodipine provides a clinically significant reduction in blood pressure in patients with hypertension. The drug does not cause acute hypotension.
Amlodipine reduces the frequency of angina attacks in patients with angina. Moreover, it reduces consumption of nitroglycerin tablets.
Amlodipine can be used in patients with asthma, diabetes and gout.
Atorvastatin decreases the concentration of cholesterol and lipoproteins. The drug reduces the concentration of total cholesterol, apolipoprotein B and triglycerides.
Atorvastatin significantly reduces the development of the following complications: coronary complications, cardiovascular complications.
Caduet (amlodipine/atorvastatin) indications for use
Caduet (amlodipine/atorvastatin) is prescribed in patients with hypertension and risk factors for cardiovascular complications (fatal and nonfatal coronary heart disease, fatal and nonfatal myocardial infarction, stroke and transient ischemic attack).
Caduet is recommended for patients in need of combination therapy of amlodipine and low doses of atorvastatin. The drug can be used with other antihypertensive or antianginal agents.
Caduet (amlodipine/atorvastatin) contraindications
Caduet (amlodipine/atorvastatin) should not be used in case of hypersensitivity to amlodipine and other dihydropyridine derivatives, atorvastatin or any other component of the drug.
The drug should not be used in case of liver disease, severe hypotension, severe aortic stenosis, during pregnancy, lactation. Women of childbearing age should use reliable forms of contraception.
Caduet is not recommended for children under the age of 18 years.
Caduet should be used with caution in liver failure, unstable angina, aortic stenosis, acute myocardial infarction, renal dysfunction, hypothyroidism, sick sinus syndrome, mitral stenosis, hypertrophic obstructive cardiomyopathy, hypotension. Also, the drug should be used with caution in patients who abuse alcohol.
Caduet is contraindicated in pregnancy and during lactation (high risk of adverse reactions).
How to use Caduet (amlodipine/atorvastatin)
The drug is taken 1 time a day at any time, regardless of mealtime.
The initial and maintenance dose should be set individually.
Caduet can be prescribed to patients who already take one of the components of the drug (as monotherapy).
Caduet is used in combination with non-medical agents, including diet, exercise, smoking cessation.
Coronary heart disease: the recommended dose is 5-10 mg once daily.
Primary hypercholesterolemia and combined dyslipidemia: the recommended dose for the majority of patients is 10 mg once daily. The therapeutic effect occurs within 2 weeks.
Patients with impaired renal function and elderly patients do not require dose adjustment.
Use the lowest effective dose of Caduet in combination with HIV protease inhibitors, HCV inhibitors, clarithromycin and itraconazole.
Caduet (amlodipine/atorvastatin) side effects
Most undesirable effects were mild to moderate. The most frequent side effects of Caduet (amlodipine/atorvastatin) include dizziness, drowsiness and headache.
Digestive tract: dyspepsia, nausea and pain in the abdomen. Infrequent side effects: allergic reactions, reduced blood sugar levels, weight gain, insomnia, depression, tinnitus. Rare side effects: low white blood cell count, vascular disorders, tachycardia, syncope, cardiac infarction and arrhythmia. Very rarely side effects: respiratory failure, cough, vomiting, bowel dysfunction with periodic constipation and diarrhea, disorders in digestive organs and urinary system.
Caduet (amlodipine/atorvastatin) interactions with other drugs
It is not recommended to combine Caduet (amlodipine/atorvastatin) with immunosuppressants (cyclosporin), macrolide antibiotics (erythromycin, clarithromycin), azole antifungals (itraconazole, ketoconazole), HIV protease inhibitors, fusidic acid.
In addition, Caduet should be taken with caution with baclofen, anticonvulsants, amifostine, beta-blockers, other antihypertensive agents and sildenafil.