Cytoxan

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Cytoxan (cyclophosphamide) Coupons, Discounts & Cost

Cytoxan (cyclophosphamide) is an alkylating antineoplastic agent. One way to save money on the Cytoxan (cyclophosphamide) retail cost regardless of income and insurance status is to use Cytoxan (cyclophosphamide) coupons or discount cards from RXCoupons. Use our Cytoxan (cyclophosphamide) coupons at your online pharmacy and receive up to 75% off the sale price each time you refill your prescription.

What is Cytoxan (cyclophosphamide)?

Cytoxan (cyclophosphamide) is an alkylating antineoplastic agent. It has a cytostatic and immunosuppressive effect. The drug is approved for use as monotherapy or in combination with other drugs for the treatment of the following diseases: acute lymphoblastic leukemia in children, acute myeloid leukemia, mammary cancer, chronic lymphocytic leukemia, chronic myeloid leukemia, Hodgkin's lymphoma, multiple myeloma, mycosis fungoides, neuroblastoma, ovarian cancer, retinoblastoma (malignant tumor of the retina), autoimmune diseases including connective tissue diseases (autoimmune hemolytic anemia, psoriatic arthritis, rheumatoid arthritis, systemic lupus erythematosus, nephrotic syndrome, multiple sclerosis).

Cyclophosphamide is sometimes used in glomerulonephritis, dermatomyositis, Wegener's granulomatosis.

What should you know about Cytoxan (cyclophosphamide) contraindications?

The main contraindications for Cytoxan (cyclophosphamide): anemia, cachexia, severe heart disease, serious liver and kidney problems, leukopenia and thrombocytopenia.

What should you know about Cytoxan (cyclophosphamide) side effects?

Common side effects of Cytoxan (cyclophosphamide) include nausea, vomiting, partial or complete loss of hair (90% of patients), dizziness, dysuria, hematuria, blurred vision, bone pain (2-3 weeks).

Cytoxan (cyclophosphamide) dosage

Different treatment regimens are available for Cytoxan (cyclophosphamide): - 200 mg (3 mg/kg) every day, or 400 mg (6 mg/kg) every other day (oral, intravenous or intramuscular injection); - 1 g (15 mg/kg) every 5 days (intravenously); - 2-3 g (30-45 mg/kg) every 2-3 weeks (intravenously).

In some cases, there may be other treatment regimens.

Cytoxan (cyclophosphamide) interaction with other drugs

Chlorpromazine, tricyclic antidepressants, barbiturates, thyroid hormones, inducers of microsomal enzymes may increase the effect of Cytoxan, while corticosteroids and inhibitors of microsomal enzymes may weaken the effect of the drug.

Doxorubicin and cytarabine increase the cardiotoxicity of the drug.

What should you know about Cytoxan (cyclophosphamide) special instructions?

In the case of febrile neutropenia or leukopenia, patients should use antibiotics or antifungal agents.

Patients with reduced immunity should be carefully monitored (for example, patients with diabetes or chronic diseases of the liver or kidney).

Patients should exclude obstruction of the urinary tract, cystitis or other infections (before therapy with cyclophosphamide).

Cardiotoxic effects of cyclophosphamide may be enhanced in patients with previous radiation therapy or concomitant therapy with anthracyclines or pentostatin.

Patients may use antiemetic drugs to reduce the severity and frequency of nausea and vomiting. Alcohol may exacerbate nausea and vomiting induced by cyclophosphamide.

Patients with diabetes must regularly check blood glucose concentration in order to improve glycemic control.

In case of cough, fever, hoarseness, painful or difficult urination, pain in the lower back, bleeding, blood in urine or feces, patients should consult a doctor immediately.

Extreme caution is required in case of thrombocytopenia during dental procedures and other invasive procedures. Such patients must carefully brush their teeth, shave, use toothpicks, avoid falls and other injuries, and avoid alcohol and acetylsalicylic acid (high risk of gastrointestinal bleeding).

It is recommended to avoid contact with infectious patients during treatment with cyclophosphamide. It is necessary to delay the vaccine (3-12 months after the completion of the last course of chemotherapy).

Some patients treated previously with cyclophosphamide or other anticancer agents may suffer from secondary malignancies. Secondary tumors often develop in patients with disorders of the immune processes. In some cases, secondary tumors develop several years after discontinuation of therapy.

When infection occurs during treatment with cyclophosphamide, the dose of the drug should be reduced.

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(Updated: November 30, -1)
Side effects of this drug makes it unworthy to try! Here are some of them that I found pretty hard to deal with or have worsened my life quality generally. First side effect I’ve noticed that it’s very unpleasant and that still haven’t disappeared even though I discontinued to use the drug: the overall texture of my hair has changed and I guess I would have never mention it here if it would change to its previous form, but no.. now it is quite similar to cotton candy or something like that, beside I have lost noticeable amount of my hair, it is a lot thinner and unhealthy. None of these have returned to their previous and normal form. i am now off this medicine for half a year (6 months). Next thing: I have had an very bad infection on my ankle that I could not heal up for full 7 months. I attribute this infection to the drug because I have had 2 more infections that were clearly caused by Cytoxan. This infection was extremely painful, not to mention how uncomfortable it was and of course very and very costly for me. I needed to go for some daily infusions of some antibiotics and besides that I had to go to visit my doctor up to 3 days per week for treatment. Besides, I was forced to wear a “boot” on that leg and foot because it was a part of my healing. Now, about those 2 other infections: they were developed in my mouth and both of them have ended up in a root canal followed by the loss of one of my big morals. As much as you can understand: again – pains, again – uncomfortable, again money. Why I know for sure that these infections are due to the drug (therefore the ankle infection too)? I was going to the dentist regularly at least 2 times per year and my dentist always told me that I’m having very good teeth and he never said that I had any of those problems. as soon as I started to take the drug, 2 mouth infections and 1 ankle infection (never had either). Coincidence? Really doubt it! there was a number of other side effects but I don’t want to mention every little thing here. Now, besides suffering from sid effects the numbers on the PFT didn’t improved at all, in fact, they went a little bit down. so, with all the information here I guess you can understand that I won’t recommend it to nobody. If I could go back in time, I would definitely never use Cytoxan again.
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