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Indocin SR


Indocin SR (indomethacin) Coupons, Discounts & Cost

Indocin is a non-steroidal anti-inflammatory drug with analgesic, antipyretic action. One way to save money on the Indocin SR (indomethacin) retail cost regardless of income and insurance status is to use Indocin SR coupons or discount cards from RXCoupons. Use our Indomethacin coupons at your online pharmacy and receive up to 75% off the sale price each time you refill your prescription.

Learn about Indocin SR

Indocin SR (indomethacin) is a synthetic drug with anti-inflammatory, analgesic, antipyretic, anti-rheumatic effect. It is used to treat rheumatoid arthritis, osteoporosis, spondylitis, rheumatism, arthritis, inflammation and swelling in the area of broken bones.

Indocin SR is an active anti-inflammatory agent for rheumatoid arthritis (characterized by chronic progressive inflammation of the joints), spondylitis (disease of the spine), osteoarthritis (disease of the joints), inflammatory diseases of the connective tissue and musculoskeletal system, thrombophlebitis (inflammation in the veins) and other diseases.

Learn about Indocin SR contraindications

Adults should avoid Indocin SR in case of hypersensitivity to the components of the drug, aspirin-exacerbated respiratory disease, peptic ulcer, ulcerative colitis, bleeding (including intracranial hemorrhage), congenital heart disease (pulmonary atresia, tetralogy of Fallot), liver cirrhosis with portal hypertension, optic nerve disease, bronchial asthma, chronic heart failure, edema, hypertension, bleeding disorders (including hemophilia, leukopenia and anemia), hepatic failure, chronic renal failure, hearing loss, vestibular pathology. The drug is not used during pregnancy, lactation.

Use with caution: hyperbilirubinemia, thrombocytopenia, epilepsy, Parkinson's disease, depression; in children and elderly patients.

Learn about Indocin SR dosage and administration

Take Indocin SR capsules during or after meals, with milk. The initial dose for adults is of 25 mg 2-3 times a day or 75 mg 1-2 times per day. Patients may increase the dose to 50 mg 3 times a day (if necessary). The maximum daily dose is 200 mg. The treatment should be continued for 4 weeks (the same or reduced dose). The maximum daily dose of indomethacin for long-term treatment is 75 mg.

Learn about Indocin SR side effects

Digestive system: abdominal pain, nausea, vomiting, heartburn, loss of appetite, diarrhea, abnormal liver function (abnormal liver enzyme levels, hyperbilirubinemia). Prolonged use at high doses: ulceration of the gastrointestinal mucosa.

Nervous system: headache, dizziness, insomnia, agitation, irritability, excessive tiredness, drowsiness, depression, peripheral neuropathy, taste disturbance, hearing loss, tinnitus, diplopia, blurred vision.

Cardiovascular system: tachyarrhythmia, edema, high blood pressure.

Urinary system: renal dysfunction, proteinuria, hematuria, interstitial nephritis, nephrotic syndrome.

Hematopoiesis and hemostasis: bleeding (including gastrointestinal, gingival, uterine bleeding), anemia (including hemolytic and aplastic anemia), leukopenia, thrombocytopenia, eosinophilia, agranulocytosis, thrombocytopenic purpura.

Allergic reactions to components of Indocin SR: skin rash, pruritus, urticaria, angioedema, bronchoconstriction; in rare cases - photosensitivity, toxic epidermal necrolysis (Lyell's syndrome), anaphylactic shock.

Other reactions: aseptic meningitis (usually in patients with autoimmune diseases), increased sweating, aplastic anemia, autoimmune hemolytic anemia, agranulocytosis, leukopenia, thrombocytopenia, hyperglycemia, glycosuria, hyperkalemia.

Indomethacin overdose: symptoms include nausea, vomiting, severe headache, dizziness, memory loss, disorientation. In severe cases - paresthesia, numbness and cramps.

Treatment: symptomatic therapy. Hemodialysis is ineffective.

Learn about Indocin SR special instructions

It is necessary to monitor liver function during treatment with indomethacin.

Patients should use antacid drugs to prevent and reduce dyspeptic symptoms.

Patients must be careful when driving during treatment with indomethacin.

Learn about Indocin SR interaction

Indomethacin may increase the concentration of digoxin and methotrexate, which can lead to increased toxicity of these drugs.

Combined therapy with paracetamol may result in high risk of nephrotoxic effects.

Combined therapy with ethanol, colchicine, corticosteroids and corticotropin may increase the risk of bleeding in the gastrointestinal tract.

Indomethacin enhances the hypoglycemic effect of insulin and oral hypoglycemic drugs, anticoagulants, antiplatelet agents, thrombolytic drugs (high risk of bleeding).

Indomethacin reduces the effect of diuretics, uricosuric and antihypertensive drugs (including beta-blockers). It strengthens the side effects of corticosteroids, estrogens, other NSAIDs.

Cyclosporine may increase the nephrotoxicity of indomethacin.

Cefamandole, ceftazidime, valproic acid may increase the risk of bleeding and hypoprothrombinemia.

Antacids and cholestyramine may reduce the absorption of the drug.

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