Janumet (sitagliptin/metformin) Coupons, Discounts & Cost
Janumet is a combination of two hypoglycemic agents - sitagliptin and metformin. One way to save money on the Janumet (sitagliptin/metformin) is a drug from the group of organic nitrates for oral use. retail cost regardless of income and insurance status is to use Janumet coupons or discount cards from RXCoupons. Use our Sitagliptin and Metformin coupons at your online pharmacy and receive up to 75% off the sale price each time you refill your prescription.
Janumet is a combination of two hypoglycemic agents - sitagliptin and metformin. It is used to improve glycemic control in patients with type 2 diabetes.
Sitagliptin increases the levels of incretin hormone (associated with regulation of glucose homeostasis). Incretins are secreted into the intestine. In case of normal or elevated blood glucose concentration, incretins enhance insulin synthesis and reduce glucose production. Incretins do not affect the synthesis of insulin and glucagon secretion in response to hypoglycemia. Sitagliptin helps increase the release of insulin and decrease glucagon secretion.
Metformin reduces the concentration of glucose and helps increase glucose tolerance. It decreases intestinal absorption of glucose and normalizes plasma lipid profile in patients with insulin-dependent diabetes mellitus: it reduces the level of triglycerides, cholesterol and LDL. Metformin also helps stabilize or reduce body weight.
Janumet indications for use
Janumet main indications: diabetes mellitus type 2 (especially in obese patients). It is used in case of ineffectiveness of diet, including in combination with sulfonylurea.
Janumet monotherapy: the drug is used in combination with diet and exercise to improve glycemic control in diabetes mellitus type 2.
Combination therapy: the drug is used to improve glycemic control in combination with metformin or PPARγ agonists (when diet and exercise are ineffective).
What are the most common contraindications for Janumet?
Janumet (metformin/sitagliptin) is contraindicated in case of hypersensitivity, kidney failure or renal disease, conditions accompanied by hypoxia (including cardiac and respiratory failure, acute phase of myocardial infarction, acute cerebrovascular insufficiency, anemia), dehydration, infectious diseases, surgery and trauma, alcoholism, acute or chronic metabolic acidosis (including diabetic ketoacidosis with coma or without coma), lactic acidosis, low-calorie diet (less than 1000 kcal/day), pregnancy, breastfeeding.
What are the most common side effects of Janumet?
Digestive tract: in the beginning of treatment - anorexia, diarrhea, nausea, vomiting, flatulence, abdominal pain, metallic taste in the mouth (3%).
Cardio-vascular system (blood, hemostasis): in rare cases - megaloblastic anemia (as a result of malabsorption of vitamin B12 and folic acid).
Metabolism: hypoglycemia; in rare cases - lactic acidosis (weakness, drowsiness, hypotension, respiratory disorders, abdominal pain, myalgia, hypothermia).
Skin disorders: rash, dermatitis.
Janumet dosage and administration
The dosage regimen should be based on the current therapy, efficacy and tolerability. The maximum recommended daily dose should not exceed 100 mg of sitagliptin. The drug is usually administered 2 times a day with meals (with gradual dose increases in order to minimize potential side effects of metformin). The initial dose of the drug depends on the current hypoglycemic therapy.
Overweight patients should follow a low-calorie diet.
Janumet should not be administered to patients with moderate or severe renal impairment.
Janumet should not be administered to patients with impaired hepatic function.
Overdose symptoms: lactic acidosis. Treatment: hemodialysis, symptomatic therapy.
Janumet interactions with other drugs
Metformin effects can be weaker in combination with thiazide diuretics, corticosteroids, phenothiazines, glucagon, thyroid hormones, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blockers. Insulin, sulfonylureas, acarbose, NSAIDs, MAO inhibitors, oxytetracycline, ACE inhibitors, clofibrate derivatives, cyclophosphamide, beta-blockers may increase the hypoglycemic effect of Janumet.
Furosemide, amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene and vancomycin may increase metformin Cmax by 60%.
Cimetidine slows the elimination of metformin and increases the risk of lactic acidosis.
Elderly patients: Due to age-related decline in renal function, older patients require regular renal function monitoring.