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Janumet

Janumet

Janumet (sitagliptin/metformin) Coupons, Discounts & Cost

Janumet is a combination of two hypoglycemic agents - sitagliptin and metformin. One way to save money on the Janumet (sitagliptin/metformin) is a drug from the group of organic nitrates for oral use. retail cost regardless of income and insurance status is to use Janumet coupons or discount cards from RXCoupons. Use our Sitagliptin and Metformin coupons at your online pharmacy and receive up to 75% off the sale price each time you refill your prescription.

Janumet action

Janumet is a combination of two hypoglycemic agents - sitagliptin and metformin. It is used to improve glycemic control in patients with type 2 diabetes.

Sitagliptin increases the levels of incretin hormone (associated with regulation of glucose homeostasis). Incretins are secreted into the intestine. In case of normal or elevated blood glucose concentration, incretins enhance insulin synthesis and reduce glucose production. Incretins do not affect the synthesis of insulin and glucagon secretion in response to hypoglycemia. Sitagliptin helps increase the release of insulin and decrease glucagon secretion.

Metformin reduces the concentration of glucose and helps increase glucose tolerance. It decreases intestinal absorption of glucose and normalizes plasma lipid profile in patients with insulin-dependent diabetes mellitus: it reduces the level of triglycerides, cholesterol and LDL. Metformin also helps stabilize or reduce body weight.

Janumet indications for use

Janumet main indications: diabetes mellitus type 2 (especially in obese patients). It is used in case of ineffectiveness of diet, including in combination with sulfonylurea.

Janumet monotherapy: the drug is used in combination with diet and exercise to improve glycemic control in diabetes mellitus type 2.

Combination therapy: the drug is used to improve glycemic control in combination with metformin or PPARγ agonists (when diet and exercise are ineffective).

What are the most common contraindications for Janumet?

Janumet (metformin/sitagliptin) is contraindicated in case of hypersensitivity, kidney failure or renal disease, conditions accompanied by hypoxia (including cardiac and respiratory failure, acute phase of myocardial infarction, acute cerebrovascular insufficiency, anemia), dehydration, infectious diseases, surgery and trauma, alcoholism, acute or chronic metabolic acidosis (including diabetic ketoacidosis with coma or without coma), lactic acidosis, low-calorie diet (less than 1000 kcal/day), pregnancy, breastfeeding.

What are the most common side effects of Janumet?

Digestive tract: in the beginning of treatment - anorexia, diarrhea, nausea, vomiting, flatulence, abdominal pain, metallic taste in the mouth (3%).

Cardio-vascular system (blood, hemostasis): in rare cases - megaloblastic anemia (as a result of malabsorption of vitamin B12 and folic acid).

Metabolism: hypoglycemia; in rare cases - lactic acidosis (weakness, drowsiness, hypotension, respiratory disorders, abdominal pain, myalgia, hypothermia).

Skin disorders: rash, dermatitis.

Janumet dosage and administration

The dosage regimen should be based on the current therapy, efficacy and tolerability. The maximum recommended daily dose should not exceed 100 mg of sitagliptin. The drug is usually administered 2 times a day with meals (with gradual dose increases in order to minimize potential side effects of metformin). The initial dose of the drug depends on the current hypoglycemic therapy.

Overweight patients should follow a low-calorie diet.

Janumet should not be administered to patients with moderate or severe renal impairment.

Janumet should not be administered to patients with impaired hepatic function.

Overdose symptoms: lactic acidosis. Treatment: hemodialysis, symptomatic therapy.

Janumet interactions with other drugs

Metformin effects can be weaker in combination with thiazide diuretics, corticosteroids, phenothiazines, glucagon, thyroid hormones, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blockers. Insulin, sulfonylureas, acarbose, NSAIDs, MAO inhibitors, oxytetracycline, ACE inhibitors, clofibrate derivatives, cyclophosphamide, beta-blockers may increase the hypoglycemic effect of Janumet.

Furosemide, amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene and vancomycin may increase metformin Cmax by 60%.

Cimetidine slows the elimination of metformin and increases the risk of lactic acidosis.

Janumet Cautions

Elderly patients: Due to age-related decline in renal function, older patients require regular renal function monitoring.

Janumet Reviews

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Wonderful medication! It works very well and I love it! within 2 days after I firstly took this drug my blood sugar levels dropped down with more than 50%!! It was 240 initially but then it went down to 110! Besides this, I have lost 6 pounds in a month or so! There is no other medication that could give me better results! I am taking 50/1000 two times per day and I am having no side effects at all. The best medication for diabetes type 2!
rds
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I took Janumet and it worked for my diabetes but I was having big troubles with intestinal issues as I was getting them very frequent. I believe me that I really got them much frequently than tolerable. I told this to my family doctor and he said that there’s a way to fix my problem. he said that Janumet is a combination of Januvia medication and Metformin medication. You can google them and you’ll see. He said that if I want, I can switch to a combination of 2 pills that includes Januvia and Metformin ER. Er means extended release. He said that if I want to switch to these 2 it may cost more but there is a chance that my intestinal distress to disappear. Yeah, when I’ve tried this way it really costs more but the good part is that my problem really disappeared. I don’t care if I have to pay a little bit more as much as nothing disturbs me anymore. yeah, it would be better to take Janumet continuously without side effects but eh… I recommend everybody else who is suffering from a similar issue to talk to their doctors and ask them if taking the combination of those two can help you. The doctor told me that many don’t have any idea that Janumet used the immediate release Metformin and exactly this thing is causing the intestinal issues that many of Janumet users are experiencing. In case you’re not experiencing intestinal issues you can stay on Janumet. But in case you’re not experiencing intestinal issues but you’re have some other side effects but it is unlikely that my recommendation would help you. However, I would discuss it anyway with a doctor. Hope this information would help anybody
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I’m a 65 years old female and just recently I’ve switched from metformin to janumet taking 50 mg/ 500 mg 1 tablet 2 times per day taken with food. Metformin seems a good medication but it doesn’t control my levels as good as before. I used metformin for years and it has maintained good results for me in all these years. It still does now but janumet does it better. The problem is that I’m suffering from frequent headaches, I have some dizziness and I’m also experiencing nausea. I’ve visited 2 different doctors each of them having 2 different suggestions for me. The first doctor said that it is going to be better staying on metformin further because it has good results, no side effects and I’ve got used to it. However, the second doctor suggested to take janumet instead of metformin because it will control my levels much more better and it would also decrease my situation if weight gain I am struggling with for years. He said that I have early stage side effects and there’s a possibility that soon they will disappear as my body would get used to this medicine. I don’t really know what to do so, I’ve been advised to continue taking janumet for one more month and see if there’s any improvement and if the side effects disappear. If they don’t then I would better go back to my old metformin. I guess it’s too early to say something about it so I cannot recommend this medication now. Everybody has to take it as his own risk.
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Simple, very commode and good acting product. I can recommend it to those who are suffering from diabetes. When I was first diagnosed with Diabetes in March 2010 I could not believe it. Anyway… I didn’t understood what happened but I passed out in my office and when I checked my blood sugar taken at that time it showed 570 or 580. I went immediately to my family doctor. Initially, he prescribed me Metformin and he said that this drug should help me. However, later we noticed that it was not controlling my blood sugar at all and there was no point to continue using it. After that he switched me to this Janumet and now my numbers are constant and I can happily report that they are in normal range. It seems weird but since I take it I have no side effects. I don’t know what I should expect after few more years of taking it but I really hope I won’t develop any. For few months I have started to work out constantly and also I have started to eat only natural products and I try to keep my diet sugar free. Even if sometimes it’s hard and I eat something it’s not really recommended for me – the results are the same so far. My sugar levels dropped dramatically and I can keep them under control anyway. Moreover, I can happily report that I lost 90-95 lbs in a year! I’m very self satisfied and I’m also very satisfied with this product! I think that you might want to give it a try.
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First, Metformin gave me crazy diarrhea, was about to quit taking it, but then it stopped. I decided to stay on this medicine because it is oral, i hate injectables. I have 3 kids, and don't wanna have dangerous sharp objects near them, from this point of view metformin is great. I take 1500mg daily, that helps my body produce the right insulin. I feel the need to drink plenty of water every time i take the pill, everything else work fine.
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