Mirapex (pramipexole) Coupons, Discounts & Cost
Mirapex (pramipexole) is a drug for the treatment of idiopathic central nervous system disorders. One way to save money on the Mirapex retail cost regardless of income and insurance status is to use Mirapex coupons or discount cards from RXCoupons. Use this Pramipexole coupon at this online pharmacy and receive up to 75% off the sale price.
Mirapex pharmacological properties
Mirapex (pramipexole) is a drug for the treatment of idiopathic central nervous system disorders. Mirapex is used to treat patients with Parkinson's disease (symptomatic monotherapy or in combined treatment with levodopa), and idiopathic restless legs syndrome (symptomatic therapy).
What are the contraindications for Mirapex?
Absolute contraindications: lactation (breastfeeding), children and teens under 18 years of age, hypersensitivity to pramipexole or other components of Mirapex.
Take medication with caution in the following cases: renal insufficiency, hypotension, pregnancy.
The tablets are taken regardless of the meal, with water. The daily dose should be divided into 3 separate doses. At the beginning of therapy, the recommended daily dose is of 0.375 mg. The dose should be gradually increased every 5-7 days (to get the maximum therapeutic effect).
Be sure to observe the following scheme: week 1: 0.375 mg per day divided into 3 doses of 0.125 mg; week 2: 0.75 mg per day divided into 3 doses of 0.25 mg; week 3: 1.5 mg per day divided into 3 doses of 0.5 mg. The maximum dose is of 4.5 mg per day. As for maintenance therapy, the individual daily dose is 0.375-4.5 mg.
Patients using this drug in the complex therapy with levodopa should reduce levodopa doses in order to prevent excessive dopaminergic stimulation. Patients with hepatic impairment should not reduce the dose.
Mirapex side effects
The most frequent adverse reactions during treatment with Mirapex: constipation and drowsiness.
Pramipexole in combination with levodopa: hallucinations and dyskinesia.
Other undesirable effects:
Nervous system: neuroleptic malignant syndrome (akathisia, muscle rigidity, hyperthermia, autonomic lability), confusion, insomnia, dizziness, extrapyramidal syndrome, delirium, amnesia, asthenia, ataxia, dystonia, tremor, depression, anxiety, hypokinesia, suicidal thoughts.
Musculoskeletal system: leg cramps, bursitis, arthritis, myasthenia gravis, neck pain, pain in the chest.
Digestive system: dyspepsia, dysphagia, abdominal pain, diarrhea, flatulence, vomiting, dry mouth.
Respiratory system: sinusitis, pharyngitis, rhinitis, shortness of breath, flu-like symptoms, cough.
Urogenital system: urinary tract infection.
Cardiovascular system: arrhythmia, tachycardia, angina pectoris, orthostatic hypotension.
Allergic reactions: retroperitoneal fibrosis, pyrexia, pleural effusion, pulmonary infiltrates, weight loss, rash, peripheral edema, decreased or increased libido.
Other reactions: conjunctivitis, diplopia, high eye pressure, cataract.
Special instructions for Mirapex
The most well-known side effects include mental confusion and hallucinations. Therefore, it is necessary to inform the patients that dopaminergic drugs can cause abnormal behavior, hyperphagia (excessive hunger), pathological shopping (obsessive desire to buy) and pathological craving for gambling. In this case, it is recommended to reduce the dose or discontinue the therapy gradually.
Antipsychotic agents should not be used simultaneously with pramipexole. Patients with severe cardiovascular disease need to be cautious when taking Mirapex, since there is a possibility of orthostatic hypotension associated with dopaminergic medications. It is recommended to control blood pressure (especially at the beginning of therapy). It is necessary to take into account the risk of sedative effect during treatment (patients may fall asleep during daily activities).
The attending physician must inform the patient of the possibility of hallucinations (mostly visual) and drowsiness during daily activities. In this regard, it is not recommended to drive until you gain sufficient experience in treating with Mirapex. You should see a doctor in cases of excessive sleepiness or falling asleep spontaneously.
Pramipexole should be used with caution with cimetidine or substances that are excreted via the renal tubules (high risk of symptoms of excessive dopamine stimulation: excitation, dyskinesia or hallucinations). It is necessary to reduce the dose in such cases.
It is necessary to reduce the dose of levodopa in case if you increase the dose of pramipexole (other antiparkinson agents should be continued at unchanged dosage).
It is recommended to be cautious while taking ethanol and other psycholeptics. Patients should avoid taking pramipexole together with antipsychotic drugs.