Nexavar (sorafenib) Coupons, Discounts & Cost
Nexavar is an anticancer drug. One way to save money on the Nexavar retail cost regardless of income and insurance status is to use Nexavar coupons or discount cards from RXCoupons. Use this Sorafenib coupon at this online pharmacy and receive up to 75% off the sale price.
What is Nexavar, indications for use
Nexavar is an anticancer drug. Its main active ingredient (sorafenib) is able to suppress the development of tumors in case of hepatocellular carcinoma and metastatic renal cell carcinoma. The drug is active even in the presence of metastases. Therefore, it can be used at stages 3 and 4 of the disease.
Nexavar dosing and administration
The recommended daily dose of Nexavar is of 400 mg (2 tablets of 200 mg). The daily dose of the drug is administered in 2 divided doses (2 times per day).
The drug is taken between meals or with meals (your food must contain low or moderate amount of fat). Swallow whole tablets with a glass of water. The treatment plan should be continued as long as determined by your physician.
Temporary interruption or dose reduction is recommended in case of possible adverse reactions. If necessary, the dosage can be reduced to 200 mg once a day.
No dose adjustment is required depending on the patient's age, gender or body weight.
No dose adjustment is required in patients with impaired liver function and mild, moderate or severe renal impairment.
Interaction with other drugs
Drugs that may reduce the concentration of sorafenib (the main component of Nexavar): phenytoin, rifampicin, carbamazepine, phenobarbital, dexamethasone, products containing St. John's wort.
Simultaneous treatment with sorafenib and warfarin should be avoided.
Sorafenib has no effect on the pharmacokinetics of gemcitabine and oxaliplatin.
Neomycin may lead to a reduction in the effect of sorafenib.
- The drug is contraindicated in the following conditions: Sensitivity to the components of the drug;
- Pregnancy and lactation;
- Pediatric patients.
Nexavar is prescribed with caution in case of skin diseases, bleeding, myocardial infarction, angina pectoris.
Nexavar therapy during pregnancy
Women should avoid becoming pregnant during treatment with sorafenib. It is necessary to use effective methods of contraception during the therapy and for at least 2 weeks after treatment with sorafenib.
Women of reproductive age should be informed of the potential risk to the fetus. Women should avoid breastfeeding during treatment with sorafenib.
Nexavar side effects
Side effects are rare.
Hematopoiesis: lymphopenia, neutropenia, anemia, thrombocytopenia. Other reactions may include bleeding, cholecystitis, renal failure, allergic reactions, fatigue, dizziness, nausea.
Cardiovascular system: very often - bleeding, high blood pressure; often - congestive heart failure, flushing; rarely - hypertensive crisis, myocardial ischemia, myocardial infarction.
Respiratory system: rarely - rhinorrhea, pneumonitis, acute respiratory distress syndrome, interstitial pneumonia.
Skin: very often - skin rash, alopecia, erythema, pruritus; often - exfoliative dermatitis, acne, dry skin; rarely - folliculitis, eczema, erythema multiforme, Stevens-Johnson syndrome; the frequency is unknown - radiation dermatitis.
Digestive system: very often - diarrhea, nausea, vomiting, abdominal pain; often - stomatitis, dryness of the oral mucosa, dyspepsia, dysphagia, anorexia, constipation; rarely - gastroesophageal reflux disease, gastritis, pancreatitis, perforation of the gastrointestinal tract, jaundice, cholecystitis, cholangitis; the frequency is unknown - drug-induced hepatitis (life-threatening symptoms have been described).
Nervous system: often - peripheral neuropathy, posterior reversible encephalopathy syndrome, depression.
Musculoskeletal system: often - arthralgia, myalgia.
Genitourinary system: often - renal failure.
Reproductive function: often - erectile dysfunction; rarely - gynecomastia.
Endocrine system: rarely - hypothyroidism, hyperthyroidism.
Allergic reactions: rarely - hypersensitivity reactions (including skin reactions and urticaria); the frequency is unknown - angioedema.
Other: hypophosphatemia, dehydration, hyponatremia, fatigue, stomach pain, headache, pain in the limbs; often - asthenia, flu-like symptoms, fever, weight loss.
Nexavar special instructions
Treatment with Nexavar may cause rash in some patients. Also, special attention should be given to blood pressure and heart rate.