Nimotop (nimodipine) Coupons, Discounts & Cost
Nimotop is a drug that affects the brain vessels (calcium channel blocker). One way to save money on the Nimotop retail cost regardless of income and insurance status is to use Nimotop coupons or discount cards from RXCoupons. Use this Nimodipine coupon at this online pharmacy and receive up to 75% off the sale price.
Nimotop mechanism of action
Nimotop is a drug that affects the brain vessels (calcium channel blocker). Nimodipine is used in the treatment of neurological ischemic disorders caused by a spasm of cerebral vessels associated with subarachnoid hemorrhage (treatment and prevention); severe functional disorders of the brain in older patients (reduced memory and concentration, emotional lability).
What are the contraindications for Nimotop?
Absolute contraindications: pediatric patients, hypersensitivity to the drug.
Additional contraindications: severe functional disorders of the liver (cirrhosis); combined treatment with rifampicin or antiepileptic drugs (phenytoin, phenobarbital, carbamazepine), pregnancy and lactation.
Relative contraindications (Nimotop should be used with caution): arterial hypotension, unstable angina or the first 4 weeks after acute myocardial infarction, elderly patients with severe renal impairment, alcoholism, hepatic disease, epilepsy, pregnancy and lactation, bradycardia, myocardial ischemia, intracranial hypertension, liver and kidney failure.
What is the dosage for Nimotop?
Nimotop capsules are taken orally with or without food (swallow whole with a small amount of liquid). The intervals between doses are at least 4 hours. The recommended single dose is 2 tablets (60 mg), the multiplicity of reception - 6 times a day for 7 days. Older patients with brain functional disorders should take 1 capsule 3 times a day.
Possible side effects
Digestive system: rarely - nausea, intestinal obstruction.
Cardiovascular system: rarely - low blood pressure, tachycardia, vasodilatation, bradycardia.
Nervous system: rarely - headache.
Immune system: rarely - rash, allergic reactions.
Hematopoiesis: rarely - thrombocytopenia.
Nimotop in elderly patients:
Nervous system: rarely - vertigo, headache, hyperkinesia, dizziness, tremors.
Digestive system: rarely - diarrhea, constipation, flatulence.
Cardiovascular system: vasodilation, low blood pressure; rarely - palpitations, syncope, tachycardia, edema.
Immune system: rarely - rash, allergic reactions.
Nimotop should be used with extreme caution in elderly patients with severe cardiovascular diseases and severe renal insufficiency. Such patients require regular medical supervision during therapy.
The bioavailability of the drug increases in severe functional disorders of the liver (especially liver cirrhosis). As a result, patients should expect possible aggravation of side effects. In this case, the dose must be reduced.
Nimotop therapy may lead to dizziness and low blood pressure (this drug may affect your ability to drive).
Store Nimotop in a dark, dry place inaccessible to children, at temperature up to 30° C.
Nimotop special instructions
Combined therapy with some drugs may cause the following effects:
- Nortriptyline (long-term therapy): a slight decrease in concentrations of nimodipine.
- Rifampicin may accelerate the metabolism and reduce the effectiveness of nimodipine.
- Fluoxetine (long-term therapy): significant increase in concentrations of nimodipine (typically by 50%) with a substantial reduction of concentration of fluoxetine.
- Drugs that inhibit or induce the activity of liver enzymes may change the concentrations of nimodipine.
- Antiepileptic drugs that induce CYP3A4 (phenytoin, phenobarbital, carbamazepine): significant reduction in the bioavailability of nimodipine (such combination is contraindicated).
- Diuretics, beta-blockers, ACE inhibitors, other calcium antagonists, alpha-blockers, methyldopa, phosphodiesterase inhibitors may lower blood pressure (careful monitoring is recommended).
- Macrolides (e.g., erythromycin), azole antifungals (e.g., ketoconazole), HIV protease inhibitors (such as ritonavir), antidepressants (nefazodone and fluoxetine), valproic acid, cimetidine may increase the concentrations of nimodipine (it is recommended to lower the dose of nimodipine).
- Calcium: reduction of nimodipine efficiency.
- Potentially nephrotoxic drugs (e.g., aminoglycosides, cephalosporins, furosemide): renal failure (use extreme caution in patients with renal insufficiency).
- Grapefruit juice: increased nimodipine concentrations.