Nitrostat (nitroglycerin) Coupons, Discounts & Cost
Nitrostat (nitroglycerin) is a drug from the group of nitrates. One way to save money on the Nitrostat retail cost regardless of income and insurance status is to use Nitrostat coupons or discount cards from RXCoupons. Use this Nitroglycerin coupon at this online pharmacy and receive up to 75% off the sale price.
Nitrostat general information
Nitrostat (nitroglycerin) is a drug from the group of nitrates. Nitroglycerin dilates blood vessels (mainly coronary/cardiac/cerebral arteries and blood vessels) and relaxes smooth muscles of the gastrointestinal tract and other organs.
Nitroglycerin reduces venous return to the heart, promotes redistribution of blood flow in the heart muscle, and improves myocardial function. Like other organic nitrates, nitroglycerine improves metabolic processes in the myocardium and helps reduce myocardial oxygen demand.
Nitrostat is used for angina attacks. Sometimes this drug helps with dyskinesia (biliary tract) and embolism (blockage) of the central retinal artery. Nitroglycerin can be also effective in case of left ventricular failure (including myocardial infarction).
Nitrostat instructions for use
Nitrostat tablets should be placed under the tongue (do not swallow until complete absorption). Higher doses: 1-2 tablets at once and 6 tablets daily.
Sublingual tablets should be kept under the tongue without swallowing. If necessary, the tablet should be immediately crushed in order to achieve a more rapid effect. You may take one more tablet within 30-40 minutes. Many patients with stable angina pectoris use lower dose (1/2 tablets). Thus, if the pain goes away quickly, the rest of the tablet should not be used.
Patients should immediately call a doctor in the absence of therapeutic effect (after 2-3 tablets).
The frequency and duration of therapy depends on the frequency and intensity of angina attacks.
When using nitroglycerin and other nitrates in various dosage forms, it should be noted that the continuous long-term treatment leads to drug resistance. Since patients usually use nitrates for a long time, they must carefully adjust the dose and constantly monitor the effectiveness of therapy.
Potential side effects
Nitroglycerin therapy may often lead to headaches, dizziness, low blood pressure (especially in the upright position).
Cardiovascular system: dizziness, headache, tachycardia, skin flushing, fever, low blood pressure; rarely (especially in case of overdose) - orthostatic collapse, cyanosis.
Digestive system: dry mouth, nausea, vomiting, abdominal pain.
CNS: rarely (especially in case of overdose) - anxiety, psychotic reactions, lethargy, disorientation.
Allergic reactions: rarely - skin rash, itching.
Other reactions: blurred vision, weakness, hypothermia.
Symptoms of overdose: reduction of blood pressure, reflex tachycardia, headache, fatigue, dizziness, drowsiness, fever, nausea, vomiting, collapse, cyanosis, methemoglobinemia, dyspnea and tachypnea.
Potential contraindications
Do not use Nitrostat in the following cases: stroke, increased intracranial pressure, severe hypotension (low blood pressure), angle-closure glaucoma, hypersensitivity. Do not use together with sildenafil.
Use with caution in the following cases: heart failure, glaucoma (risk of increased intraocular pressure), severe anemia, hyperthyroidism, hypotension with a low systolic blood pressure (may cause paradoxical bradycardia and angina), severe renal failure, hepatic failure (risk of methemoglobinemia), malabsorption syndrome, pregnancy, lactation, age under 18 years.
Interactions
Sildenafil, vasodilators, antihypertensive drugs, ACE inhibitors, beta-blockers, procainamide, tricyclic antidepressants, MAO inhibitors, PDE inhibitors, as well as ethanol may enhance the hypotensive effect of Nitrostat. Dihydroergotamine may lead to an increase in blood pressure. Co-administration with heparin reduces the effectiveness of heparin.
Nitrostat special instructions
Patients should avoid abrupt withdrawal in order to prevent the increased frequency of angina attacks. Patients who used organic nitrates previously (isosorbide dinitrate, isosorbide-5-mononitrate) may need a higher dose to obtain the desired hemodynamic effect.
Nitroglycerin therapy may cause a significant reduction in blood pressure (when using ethanol, in case of physical exercises and hot weather) up to myocardial infarction and sudden death (paradoxical reaction).
Long-term therapy without intervals may cause tolerance (higher dosages needed). Treatment should be discontinued if symptoms such as blurred vision or dry mouth are strongly expressed.