Principen (ampicillin) Coupons, Discounts & Cost
Principen (ampicillin) is an antibiotic from the group of penicillins that suppresses the activity of many gram-negative and gram-positive bacteria. One way to save money on the Principen retail cost regardless of income and insurance status is to use Principen coupons or discount cards from RXCoupons. Use this Ampicillin coupon at this online pharmacy and receive up to 75% off the sale price.
What should you know about Principen?
Principen (ampicillin) is an antibiotic from the group of penicillins that suppresses the activity of many gram-negative and gram-positive bacteria. It is useful in pathologies that are caused by mixed infections: pneumonia, bronchopneumonia, lung abscess, peritonitis, cholecystitis, sepsis, gonorrhea, intestinal infections, urinary tract infections, postoperative infections of soft tissues, other infections caused by ampicillin-sensitive microorganisms.
Ampicillin is well absorbed from the digestive tract. It penetrates into tissues and body fluids and can be found in therapeutic concentrations in the pleural, peritoneal and synovial fluids. 30% of ampicillin is metabolized in the liver. It is excreted mainly with urine (partially with bile).
Principen is not prescribed to patients with hypersensitivity to ampicillin, infectious mononucleosis and violations of the liver function.
How to use Principen
The drug is prescribed regardless of the meal.
Adults: a single dose is of 250-500 mg 4 times per day. Children with body weight up to 20 kg - 12.5-25 mg per kg every 6 hours. The maximum daily dose for adults is 4 g. The duration of treatment depends on the severity of the disease and the effectiveness of therapy.
Unwanted side effects
Ampicillin can cause the following negative reactions: skin rash, urticaria, anaphylactic shock, angioedema, rhinitis, fever, exfoliative dermatitis, arthralgia, conjunctivitis, stomatitis, gastritis, abdominal pain, nausea, vomiting, diarrhea, tremor, headaches, convulsions.
Allergic reactions: skin rash, hives, Quincke's edema, itching, exfoliative dermatitis, erythema multiforme; in rare cases - anaphylactic shock.
Digestive system: nausea, vomiting, diarrhea, glossitis, stomatitis, pseudomembranous colitis, intestinal dysbiosis.
Hematopoiesis: anemia, leukopenia, thrombocytopenia, agranulocytosis.
Central nervous system: agitation or aggressiveness, anxiety, confusion, depression, convulsions (with high-dose therapy).
Effects caused by chemotherapeutic action of the drug: candidiasis of the oral cavity, vaginal candidiasis.
Overdose symptoms: toxic effects on the central nervous system (especially in patients with renal insufficiency), nausea, vomiting, diarrhea.
Overdose treatment: gastric lavage, symptomatic treatment.
Information on drug interactions
Probenecid reduces tubular secretion of ampicillin. As a result, the risk of toxic effect increases.
Ampicillin and allopurinol increase the risk of skin rash.
Ampicillin reduces the effectiveness of estrogen-containing oral contraceptives.
Ampicillin may increase the effectiveness of indirect anticoagulants and aminoglycosides.
Antacids, glucosamine, laxatives and food may slow down and reduce the absorption of ampicillin. Ascorbic acid increases the absorption of ampicillin.
Aminoglycosides, cephalosporins, vancomycin, rifampicin, macrolides, chloramphenicol, lincosamides, tetracyclines, and sulfonamides should be used with caution together with ampicillin.
Ampicillin reduces the effectiveness of ethinylestradiol (the risk of bleeding increases).
Diuretics, oxyphenbutazone, phenylbutazone, NSAIDs increase the concentration of ampicillin.
Ampicillin increases the toxicity of methotrexate.
Ampicillin increases the absorption of digoxin.
Patients with renal insufficiency may suffer from toxic effects when using high doses of Principen.
Parenteral administration is contraindicated in case of severe violations of liver function.
Patients with impaired renal function should correct the dosing regimen. Toxic effect on the CNS is expected when using the drug in high doses in patients with renal insufficiency.
One should use Principen with caution in case of bronchial asthma, hay fever and other allergic diseases.
Weakened patients may suffer from superinfection caused by ampicillin resistant microorganisms (in case of long-term use of the drug).
Ampicillin should be stored at a temperature not exceeding 25° C, in a dry place, out of the reach of children.