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Sinemet (carbidopa/levodopa) Coupons, Discounts & Cost

Sinemet is an antiparkinsonian drug consisting of levodopa and carbidopa. One way to save money on the Sinemet retail cost regardless of income and insurance status is to use Sinemet coupons or discount cards from RXCoupons. Use this Carbidopa/Levodopa coupon at this online pharmacy and receive up to 75% off the sale price.

What is Sinemet?

Sinemet is an antiparkinsonian drug consisting of levodopa and carbidopa. Sinemet reduces the risk of hypokinesia, rigidity, tremor, dysphagia. Levodopa helps fight with dopamine deficiency in the central nervous system. Carbidopa reduces the formation of dopamine in peripheral tissues, which leads to an increase in the amount of levodopa entering the central nervous system.

The effect of the drug can be felt within the first 24 hours (sometimes after the first dose). The full effect is achieved within 7 days.

Sinemet indications for the use: Parkinson's disease, Parkinson's syndrome associated with cerebrovascular diseases, intoxication with certain substances (including carbon monoxide poisoning).

Sinemet contraindications

Sinemet should not be taken in case of hypersensitivity, angle-closure glaucoma, severe psychosis or psychoneurosis, melanoma, skin diseases of unknown etiology, pregnancy, lactation. Sinemet should not be taken by children up to 12 years.

It is necessary to consult with your doctor before starting Sinemet therapy in case of myocardial infarction with rhythm disturbances, bronchial asthma, lung diseases, epileptic seizures, erosive and ulcerative lesions of the digestive tract, diabetes mellitus, endocrine diseases, severe hepatic or renal insufficiency, CHF.

How should I take Sinemet?

Take 1/4 tablets 2-3 times a day, then increase the dose by 1/4 every 2-3 days. The optimal effect is observed at a dose of 1-2 tablets per day. The maximum daily dose is 1.5 g of levodopa and 150 mg of carbidopa (6 tablets of 250 mg / 25 mg).

It is recommended to take this drug with food or with a small amount of liquid (the capsules should be swallowed whole).

Possible side effects of the drug

At the beginning of treatment: nausea, vomiting, loss of appetite, epigastric pain, dysphagia; in some cases - rhythm disturbances, orthostatic hypotension.

Further treatment: hyperkinesis, dyskinesia, hemolytic anemia, leukopenia, thrombocytopenia, mental disorders, insomnia, depression, tachycardia, constipation, weight gain (during long-term therapy).

Central nervous system: dyskinesia, hallucinations, confusion, weakness, nightmares, dystonia, sleep disorders, depression, asthenia, headache, disorientation, paresthesia, extrapyramidal disorders, agitation, anxiety, depression, depressions with suicidal tendencies, dementia, euphoria, ataxia, syncope, tremor. It is necessary to reduce the dose of the drug in case of muscle cramps, dyskinesia and blepharospasm.

Digestive system: nausea, dry mouth, vomiting, anorexia, constipation, epigastric pain, diarrhea, flatulence, hiccups, burning sensation in the mouth, gastrointestinal bleeding and ulcers.

Cardiovascular system: dyspnea, tachycardia, phlebitis, hypotension, swelling.

Genitourinary system: delayed urination, enuresis, hematuria, priapism.

Skin: excessive sweating, rash, alopecia.

Other reactions: diplopia, dilated pupils, fever, hyperemia, changes in body weight.

What about Sinemet special instructions?

Do not stop taking levodopa suddenly (high risk of neuroleptic syndrome, including muscle rigidity, high body temperature, etc.).

It is necessary to monitor patients who use antipsychotic drugs. It is necessary to monitor the patient's mental status during treatment.

Avoid foods high in protein during treatment.

Patients with glaucoma should regularly monitor intraocular pressure.

Care must be taken when driving during the treatment period.

What should I know about possible interactions?

There may be an increased risk of heart rhythm disturbances if you use levodopa with drugs for inhalation anesthesia.

Tricyclic antidepressants may reduce the bioavailability of levodopa.

Diazepam, phenytoin, clozapine, clonidine, certain antipsychotic drugs (neuroleptics), pyridoxine, papaverine, reserpine may reduce the effect of Sinemet.

Circulatory disorders are possible if you use levodopa with MAO inhibitors (MAO inhibitors should be discontinued before you start treatment with Sinemet). There is a high risk of high blood pressure, tachycardia and dizziness.

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