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Sustiva (efavirenz) Coupons, Discounts & Cost

Sustiva (efavirenz) is an antiviral synthetic drug that demonstrates activity against HIV. One way to save money on the Sustiva retail cost regardless of income and insurance status is to use Sustiva coupons or discount cards from RXCoupons. Use this Efavirenz coupon at this online pharmacy and receive up to 75% off the sale price.

What should I know about Sustiva?

Sustiva (efavirenz) is an antiviral synthetic drug that demonstrates activity against HIV.

Learn about Sustiva contraindications

Sustiva is not prescribed in the following conditions: - Liver failure (medium and severe degree); - Combination therapy with cisapride, astemizole, terfenadine, triazolam, pimozide, midazolam, ergot alkaloids (dihydroergotamine, ergotamine, methylergonovine); - Combination therapy with products of plant origin containing St. John's wort; - Hypersensitivity to any component of the drug; - Children under 3 years old, children with body weight less than 13 kg.

It is important to know that Sustiva is used with caution in the following cases: - Psychiatric disorders in patients; - Liver disease (mild and moderate severity); - Convulsions; - Combination therapy with certain anticonvulsant drugs, such as phenobarbital, phenytoin and carbamazepine.

How should you use Sustiva?

Sustiva capsules should be taken at bedtime and on an empty stomach (food may increase the frequency of side effects). Sustiva is used in combination with other antiretroviral agents.

Adults: 600 mg once a day in combination with nucleoside reverse transcriptase inhibitors or with a protease inhibitor. It should be borne in mind that the dose of efavirenz should be higher (up to 800 mg) if Sustiva is used in combination with rifampicin in patients with a body weight of 50 kg. If used simultaneously with voriconazole, the dose of the latter should be increased to 400 mg twice a day. At the same time, the dose of efavirenz should be reduced by 50% (up to 300 mg).

Children with a body weight of more than 13 kg: Sustiva is used in combination with a protease inhibitor and/or NRTI. Recommended doses depending on the weight: 13-15 kg - 200 mg; 15-20 kg - 250 mg; 20-25 kg - 300 mg; 25-32 kg - 350 mg; 32.5-40 kg - 400 mg; more than 40 kg - 600 mg.

Learn about Sustiva side effects

Skin and subcutaneous tissues: very often - skin rash; often - skin itching; rarely - Stevens-Johnson syndrome, dermatitis.

Mental disorders: often - insomnia, depression, anxiety; rarely - paranoid personality disorder, aggressiveness, hallucinations, mania, suicidal attempts, neurosis, delirium.

Disorders of the nervous system: often - dizziness, headaches, drowsiness; rarely - ataxia, convulsions, amnesia, anxiety, tremor.

Disorders of the immune system: rarely - hypersensitivity reactions.

Disorders of the liver and bile ducts: often - acute hepatitis; rarely - liver failure.

Disorders of the gastrointestinal tract: often - pain in the abdomen, nausea, diarrhea, vomiting; rarely - pancreatitis, gynecomastia, vertigo, tinnitus.

Disorders of metabolism: often - hypertriglyceridemia; rarely - hypercholesterolemia.

What should you know about Sustiva precautions?

Sustiva should not be used as monotherapy for HIV infection. It is not recommended to use Sustiva simultaneously with certain drugs (in a tablet form) with fixed-dose combinations of emtricitabine, efavirenz, tenofovir disoproxil fumarate.

Sustiva can cause certain side effects, including insomnia and dizziness (it is recommended to refrain from driving in case of severe side effects).

What should you know about Sustiva interactions?

Do not use Sustiva with the following drugs: astemizole, midazolam, bepridil, terfenadine, cisapride, ergot alkaloids. Such combinations can lead to serious and even life-threatening consequences.

Do not take drugs or products containing St. John's Wort, as they can significantly reduce efavirenz concentrations.

It is not recommended to take Sustiva capsules in combination with ritonavir and atazanavir, as well as in combination with saquinavir, proguanil, posaconazole.

Efavirenz reduces the concentrations of indinavir, boceprevir, voriconazole.

Ritonavir used in low doses may increase the incidence of adverse events associated with efavirenz therapy.

Efavirenz reduces the concentration of clarithromycin (it is recommended to use another antibiotic).

Rifampicin reduces the concentration of efavirenz.

Caution should be exercised when using valproic acid (patients should be under medical supervision to control convulsive seizures).

Sustiva reduces the effectiveness of hormonal contraceptives. Patients should be under close medical supervision if they use methadone.

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