Vesicare (solifenacin) Coupons, Discounts & Cost
Vesicare (solifenacin) is a drug that works in the urinary tract. One way to save money on the Vesicare retail cost regardless of income and insurance status is to use Vesicare coupons or discount cards from RXCoupons. Use this Solifenacin coupon at this online pharmacy and receive up to 75% off the sale price.
Vesicare pharmacologic effect
Vesicare (solifenacin) is a drug that works in the urinary tract. It is used to treat urological diseases. Vesicare is effective in case of urinary incontinence and frequent urination (signs of hyperactive bladder syndrome).
Vesicare contraindications
Absolute contraindications: severe hepatic impairment, certain gastrointestinal diseases (including toxic megacolon), delayed urination, closed-angle glaucoma, severe renal insufficiency, myasthenia gravis, hereditary galactose tolerance, lactase deficiency, glucose-galactose malabsorption, age up to 18 years, lactation, hypersensitivity to the components of the drug.
Relative contraindications (use with extreme caution): bladder outlet obstruction, gastrointestinal obstructive diseases (including stagnation of food in the stomach), severe renal and moderate hepatic insufficiency (the dose of Vesicare should not exceed 5 mg for such patients), hiatal hernia, gastroesophageal reflux, autonomic neuropathy, pregnancy.
Vesicare instructions for use
Vesicare tablets should be taken with enough liquid. Swallow the tablets regardless of meals.
Adult patients are prescribed 5 mg once a day at the beginning of treatment. If necessary, increase the dose to 10 mg once a day.
Patients with renal insufficiency: patients with mild to moderate renal failure should not change the dose. Patients with severe renal insufficiency should take the drug at a dose of no more than 5 mg once a day.
Patients with hepatic insufficiency: it is not necessary to change the dose for patients with moderate hepatic insufficiency. Patients with severe hepatic insufficiency should take the drug with caution (do not exceed the dosage of 5 mg once a day).
The maximum dose of Vesicare should be limited to 5 mg for those who take strong inhibitors of CYP3A4 (ritonavir, nelfinavir, itraconazole).
Vesicare side effects
The most common side effects of Vesicare: dry mouth, nausea, indigestion, abdominal pain, constipation, blurred vision, gastroesophageal reflux disease, dryness of nasal cavity, urinary tract infections, cystitis, difficulty urinating, urinary retention, drowsiness, peripheral edema, dry skin.
Other side effects: vomiting, intestinal obstruction, polymorphic erythema, skin rash, itching, urticaria, hallucinations, psychosis.
Digestive system: often - dyspepsia, nausea, abdominal pain, constipation; rarely - gastroesophageal reflux disease, intestinal obstruction; very rarely - vomiting, hyperkalemia.
Urinary system: rarely - difficulty urinating, urinary tract infection, urine retention; very rarely - renal failure.
Central nervous system: rarely - drowsiness; very rarely - headache and dizziness, hallucinations.
Respiratory system: rarely - dryness of the nasal mucosa.
Cardiovascular system: tachycardia.
Skin and subcutaneous tissue: rarely - dry skin; very rarely - rash, itching, urticaria, exfoliative dermatitis, erythema multiforme, angioedema.
Allergic reactions: anaphylactic reactions.
Other: rarely - fatigue.
Vesicare special instructions
Patients must undergo a full medical examination to determine whether there are other causes of urinary disorders (such as kidney disease or heart failure). Antimicrobial therapy is prescribed in case of urinary tract infections.
Care should be taken when prescribing this drug to pregnant women. It is not recommended to use Vesicare during breastfeeding.
The drug should not be used in children and adolescents under 18 years of age.
Solifenacin can cause blurred vision, fatigue and drowsiness. For this reason, special care should be taken when driving vehicles during the whole treatment period.
Vesicare reduces the effectiveness of drugs that stimulate the motility of the gastrointestinal tract (for example, cisapride and metoclopramide).
Ketoconazole may double the total concentration of solifenacin in the blood. Therefore, the dose of Vesicare should not exceed 5 mg per day (when used with ketoconazole, nelfinavir, ritonavir, itraconazole). This combination is contraindicated in patients with moderate hepatic insufficiency and severe renal insufficiency.
Solifenacin should be used with caution with diltiazem, verapamil, phenytoin, rifampicin, carbamazepine.