Rebetol (ribavirin) Coupons, Discounts & Cost
Rebetol (ribavirin) is an antiviral drug, which is active against certain RNA and DNA containing viruses. One way to save money on the Rebetol retail cost regardless of income and insurance status is to use Rebetol coupons or discount cards from RXCoupons. Use this Ribavirin coupon at this online pharmacy and receive up to 75% off the sale price.
Pharmacological action of Rebetol
Rebetol (ribavirin) is an antiviral drug, which is active against certain RNA and DNA containing viruses. Rebetol indications for use: - Combination therapy with interferon alfa products in chronic hepatitis C (if relapse occurs); - Chronic hepatitis C (previously untreated).
Rebetol contraindications
This drug should not be used in patients up to 18 years of age. Rebetol is not prescribed in case of severe forms of heart disease (diagnosed within 6 months prior to initiation of therapy), sickle-cell anemia, thalassemia and other types of hemoglobinopathies, thyroid gland pathologies (resistant to therapy), severe forms of liver disorders, decompensated cirrhosis of the liver, autoimmune hepatitis and other autoimmune diseases, chronic renal failure, severe depression, suicide attempts, suicidal thoughts. Rebetol should not be used in case of intolerance to ribavirin and other components of the drug, as well as during the period of pregnancy and breastfeeding. Rebetol is used with caution in patients with other heart diseases, diabetes mellitus, severe lung diseases (including chronic obstructive pulmonary diseases), disorders of the coagulation system (including pulmonary embolism, thrombophlebitis). The drug should be avoided in patients with concomitant HIV infection (due to the high risk of lactic acidosis).
Rebetol dosage and administration
Rebetol capsules are taken during meals. The daily dose of Rebetol ranges from 0.8 g to 1.2 g (divided into 2 doses, morning and evening). The drug is prescribed in combination with interferon alfa products. The recommended daily dosage regimen: - Patient weighting 75 kg or less: 1 g (0.4 g in the morning and 0.6 g in the evening); - Patient weighting more than 75 kg: 1.2 g (0.6 g in the morning and in the evening). The recommended duration of combined therapy is no more than 12 months. The duration depends on the tolerability and the therapeutic effect. Dose adjustment or temporary withdrawal of therapy is required in case of serious adverse effects. Rebetol therapy should be canceled if there is no improvement in the patient's condition.
Rebetol side effects
Hematopoietic system: moderate anemia, neutropenia, leukopenia, thrombocytopenia, granulocytopenia; rarely - aplastic anemia. Cardiovascular system: palpitation, pain in the chest, tachycardia. Nervous system: insomnia, depression, irritability, headache, dizziness, anxiety, paresthesia, tremor, confusion, hyperesthesia, hypoesthesia, nervousness, emotional lability; rarely - suicidal thoughts or attempts. Endocrine system: hypothyroidism, disorders of the thyroid gland. Digestive system: nausea, vomiting, abdominal pain, diarrhea, constipation, anorexia, dyspepsia, pancreatitis, stomatitis, flatulence, glossitis. Reproductive system: decreased libido, menorrhagia, amenorrhea, prostatitis. Respiratory system: dyspnea, cough, pharyngitis, bronchitis, rhinitis, sinusitis. Musculoskeletal system: myalgia, arthralgia. Dermatological reactions: dry skin, pruritus, rash, alopecia, erythema, eczema, herpetic infection; rarely - Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis. Other: conjunctivitis, tinnitus, allergic reactions, thirst, dry mouth, otitis media, weakness, flu-like syndrome, fever, increased sweating, weight loss, asthenia, viral infection, fungal infection, lymphadenopathy.
Rebetol special instructions
Rebetol should be given with particular caution to patients with heart diseases (the risk of anemia is higher in this category of patients). Therefore, Rebetol therapy should be stopped in case of worsening of symptoms. Treatment should be stopped in case of symptoms of bronchospasm, urticaria, angioedema, anaphylaxis. Women of childbearing age can use this drug only if they are not pregnant. There is a significant risk of teratogenic effects of ribavirin on the fetus (in case of pregnancy). Rebetol can cause drowsiness, disorientation, fatigue. Therefore, it is recommended to avoid driving during the period of therapy.
Drug interactions
Antacids containing simethicone and aluminum or magnesium compounds may reduce the bioavailability of ribavirin. Didanosine and abacavir increase the risk of lactic acidosis.