Demadex (torsemide) Coupons, Discounts & Cost
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General information for Demadex (torsemide)
Demadex (torsemide) is one of the most effective modern loop diuretics. It acts up to 12 hours. The drug is recommended for hypertension and cardiac edema (including in patients with chronic heart failure, liver and kidney diseases). The maximum daily dose should not exceed 200 mg.
What are the precautions when using Demadex (torsemide)?
Avoid Demadex (torsemide) in case of hypersensitivity (including to sulfonamides), anuria, hepatic coma and precoma, progressive azotemia, hypotension, arrhythmia.
The drug is prescribed with caution during pregnancy, breastfeeding, as well as in patients under 18 years of age.
Use with caution in people predisposed to hyperuricemia, gout, and those with diabetes.
Demadex (torsemide) during pregnancy and lactation
Demadex (torsemide) is not recommended during pregnancy due to the potential risk to mother and fetus. However, diuretics can be taken for the treatment of hypertension, which existed prior to pregnancy. Diuretics can be used to treat edema in patients with severe hypervolemia.
How should you use Demadex (torsemide)?
The usual dose is 5-20 mg 1 time per day (depending on the indication).
A single dose of 40 mg is not recommended. The drug should be used for a long time or until disappearance of edema.
What are some side effects of Demadex (torsemide)?
Metabolism: rarely - hypercholesterolemia, hypertriglyceridemia, polydipsia. Nervous system: often - dizziness, headache, drowsiness; rarely - muscle spasms of the lower limbs, confusion, paresthesia of the extremities. Cardiovascular system: rarely - extrasystole, tachycardia, palpitation, hypotension, deep venous thrombosis, thromboembolism, hypovolemia. Respiratory system: rarely - nosebleeds. Digestive system: often - diarrhea; rarely - abdominal pain, bloating, nausea, vomiting, loss of appetite, pancreatitis, dyspeptic symptoms. Kidneys and urinary tract: often - frequent urination, polyuria, nocturia; rarely - urinary retention (in patients with urinary tract obstruction). Other reactions: rarely - hyperglycemia, hyperuricemia, hypokalemia, hyponatremia, hyposalemia, metabolic alkalosis, blurred vision, ringing in the ears and hearing loss (it is usually reversible), weakness, thirst, hyperactivity, nervousness, fatigue. Skin problems: itching, rash, photosensitivity (the frequency is unknown).
Demadex (torsemide) interactions
Torsemide may increase the toxicity of cardiac glycosides.
Glucocorticoids and laxatives may increase potassium excretion.
Torsemide enhances the effect of antihypertensive drugs, salicylates.
Torsemide (especially in high doses) may enhance the nephrotoxicity and ototoxicity of certain antibiotics, platinum agents, cephalosporins.
Torsemide may increase the effects of muscle relaxants and theophylline.
Torsemide reduces the effect of hypoglycemic drugs.
When used with ACE inhibitors, torsemide may lead to a short-term drop in blood pressure. Patients should reduce the initial dose of ACE inhibitors or lower the dose of torsemide (or stop taking the medication at least temporarily).
NSAIDs and probenecid may reduce the diuretic and hypotensive effect of torsemide.
The bioavailability of torsemide can be reduced in combination therapy with colestyramine.
Torsemide may increase the toxicity of drugs containing lithium and ototoxicity of ethacrynic acid.
Demadex (torsemide) special instructions
Demadex (torsemide) is 3 times more potent than furosemide.
Demadex overdose symptoms: forced diuresis, lethargy, hypovolemia, reduction of blood pressure (up to collapse), electrolyte imbalance, confusion. Stop using the drug or reduce the dose in case of overdose.
Demadex may be used during pregnancy only under the strict supervision of the attending physician. He should carefully weigh the potential benefits to the mother and the potential risk to the fetus. Women should stop breastfeeding (after consultation with the attending physician).