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Augmentin (amoxicillin) - instructions for use
Augmentin belongs to the group of antibiotics with a broad spectrum of activity. The drug combines amoxicillin and clavulanic acid.
The main active substance - amoxicillin - shows high therapeutic activity against gram-positive and some gram-negative microorganisms. Amoxicillin is not used to kill beta-lactamase-producing pathogens.
Clavulanic acid is able to kill beta-lactamases and other enzymes produced by pathogenic micro-organisms, which are resistant to penicillin and cephalosporin. Clavulanic acid enhances the antibacterial activity of the drug. Through this component Augmentin may kill the pathogens that are highly resistant to both penicillins and cephalosporins.
Augmentin (amoxicillin) effect on bacteria
Augmentin is active against gram-positive and gram-negative aerobic and anaerobic pathogens, as well as some other pathogens that cause serious infections.
The drug is active against Chlamydia, Treponema pallidum (syphilis), bacteria that cause leptospirosis, Staphylococcus, Streptococcus, Clostridium, Brucella, Gardnerella vaginalis, Salmonella, Shigella, Vibrio cholerae, and other microorganisms.
Augmentin is a long-acting drug that can be used to destroy pathogens of pneumonia, which are resistant to penicillins.
Augmentin (amoxicillin) pharmacological properties
The maximum therapeutic effect of the drug is observed if the patient takes the pill before meals. The active ingredients are rapidly dissolved and absorbed in the digestive tract.
Amoxicillin can pass into human milk. Therefore, Augmentin is usually not prescribed for lactating women due to the high risk of drug accumulation.
Amoxicillin and clavulanic acid are mainly excreted by the kidneys.
When to take Augmentin (amoxicillin)
The main indications for Augmentin tablets: - Upper respiratory tract infections (sinusitis, otitis media, pharyngitis, tonsillitis, bronchitis caused by Streptococcus pneumoniae or Staphylococcus Aureus); - Lower respiratory tract infections (chronic bronchitis, pneumonia, acute lung tissue inflammation; - Infectious diseases of the genitourinary system (inflammation of the bladder, kidney inflammation diseases, gonorrhea, chlamydia; - Pustular skin disorders (pyoderma, carbuncles and other disorders); - Bone and joint infections (osteomyelitis caused by Staphylococcus Aureus); - Complications after difficult births or abortion (endometritis, other diseases of the reproductive system); - Therapy of mixed abdominal infections (complex treatment with other drugs).
Augmentin (amoxicillin) dosage
The course of treatment must be set for each patient individually. It is important to remember that Augmentin is an antibiotic, so the dosage may depend on many factors including the patient's age, diagnosis, complications, kidney and liver function, body weight, etc.
It is better to take Augmentin pills before meals in order to increase the absorption of the drug and reduce the risk of side effects.
The minimum duration of treatment should be at least 5 days. Do not stop treatment even if all symptoms disappear. Note that pathogenic microorganisms rapidly become resistant to the drugs. If your treatment is interrupted, symptoms will return.
If the patient takes the drug more than 10 days, further treatment studies may be needed.
Augmentin (amoxicillin) side effects
Augmentin dosages are generally well tolerated by most patients. In some cases, the following side effects develop: - Digestive tract: nausea, pain in the stomach, bloating, flatulence, vomiting, diarrhea, abnormal liver function; - Urinary organs: acute renal failure, oliguria, kidney failure; - Central nervous system: dizziness, headaches, insomnia or drowsiness, symptoms of intoxication, weakness.
The most common side effects include allergic skin rash, hives, thrush (vaginal and oral candidiasis).
Most patients have few or only minor side effects when they use the dose of Augmentin stated in the prescription.
Augmentin (amoxicillin) contraindications
Augmentin tablets have the following clinical contraindications: individual intolerance to penicillins and cephalosporins, severe liver and kidney damage, infectious mononucleosis. Augmentin should not be taken by any child under 2 years old.