Clozaril (clozapine) Coupons, Discounts & Cost
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General information about Clozaril (clozapine)
Clozaril (clozapine) is a neuroleptic drug with sedative effect. Clozapine has a strong anticholinergic, antiadrenergic, antihistamine, antipsychotic effect. It demonstrates a pronounced and rapid sedation in patients with schizophrenia.
As compared with other antipsychotic drugs, Clozaril causes mild extrapyramidal reactions (acute dystonia, akathisia, parkinsonian effects).
The drug is used to treat sleep disorders, acute and chronic forms of schizophrenia, psychomotor agitation in schizophrenia, delusions and hallucinations, mania (including inadequately elevated mood, psychomotor agitation), other behavioral and emotional disorders.
In what case you should not use Clozaril (clozapine)
In some cases, Clozaril (clozapine) should not be used: granulocytopenia, agranulocytosis, drug intoxication, coma, vascular insufficiency, severe renal or cardiac failure, progressive liver disease, hepatic failure, acute alcohol psychosis, severe diseases of the cardiovascular system, epilepsy, glaucoma, prostate adenoma, intestinal atony, hypersensitivity to the drug.
The drug is not used for the treatment of women during pregnancy (especially during the first trimester of pregnancy) and breastfeeding (lactation should be discontinued), as well as for the treatment of children under 16 years.
How to take the drug
Clozaril (clozapine) in the form of tablets can be taken regardless of the meal. The initial single dose is 50-100 mg, the multiplicity of reception - 2-3 times a day. The daily dose may be increased to 200-600 mg if necessary. The highest dose is 600 mg per day.
Patients with renal, liver, heart disease and cerebrovascular disorders should use the drug in small doses - from 25 to 200 mg per day.
Maintenance therapy: take clozapine in the evening at a dose of 25-200 mg.
What side effects may occur while using the drug?
Clozaril (clozapine) may cause the following side effects: dry mouth, confusion, delirium, drowsiness, muscle weakness, orthostatic hypotension, tachycardia, disturbance of accommodation. In the case of agranulocytosis, the therapy should be interrupted immediately. CNS: headache, agitation, somnolence, akathisia, tardive dyskinesia, insomnia, depression, confusion, seizures, fever. Digestive system: nausea, hypersalivation, dry mouth, vomiting, heartburn. Metabolism: weight gain, sweating. Anticholinergic reactions: urination disorders, disorders of accommodation, constipation. Other reactions: reduced potency in men, hypotension, tachycardia, orthostatic hypotension, arterial hypertension, eosinophilia, granulocytopenia, leukopenia, agranulocytosis, thrombocytopenia. Symptoms of overdose: drowsiness, areflexia, confusion, coma, hallucinations, delirium, hyperreflexia, extrapyramidal symptoms, seizures, arrhythmia, mydriasis, hypotension, tachycardia, aspiration pneumonia, respiratory depression. Overdose treatment: gastric lavage, symptomatic treatment.
Clozaril (clozapine) interactions
Drugs which depress the nervous system may increase the severity of side effects and cause respiratory depression.
Clozaril should be combined with caution with antihypertensive agents, digoxin, phenytoin, and carbamazepine (these agents may cause severe pancytopenia and neuroleptic malignant syndrome).
Caffeine, paroxetine, fluoxetine, sertraline, fluvoxamine, ciprofloxacin and clozapine may increase the risk of side effects.
Concomitant administration with warfarin may be associated with severe adverse medical reactions.
Lithium carbonate may cause myoclonus, seizures, delirium, neuroleptic syndrome, psychosis.
Rifampicin inhibits the metabolism of clozapine.
Clozaril (clozapine) special instructions
Patients should consult a doctor before they start using the drug and in cases of atypical symptoms. Your doctor should advise you not to drive during therapy.
Caution is advised for patients with severe disorders of the circulatory system, severe liver failure or kidney disorders, glaucoma, prostatic hyperplasia, epilepsy, intestinal atony.
Clozaril (clozapine) conditions of storage
Store in a cool, dry place, inaccessible to children.