Neoral (ciclosporin) Coupons, Discounts & Cost
Cyclosporine is a synthetic immunosuppressive drug used to prevent rejection after organ transplantation. One way to save money on the Neoral retail cost regardless of income and insurance status is to use Neoral coupons or discount cards from RXCoupons. Use this Ciclosporin coupon at this online pharmacy and receive up to 75% off the sale price.
General description
Cyclosporine is a synthetic immunosuppressive drug used to prevent rejection after organ transplantation. The active ingredient has immunosuppressive action: it slows the reaction of humoral and cellular immunity.
Patients taking Neoral are less prone to infections than patients receiving other immunosuppressive drugs.
Neoral indications: cyclosporine is prescribed in conjunction with other immunosuppressive drugs and corticosteroids for the prevention of organ transplant rejection (kidneys, bone marrow, heart, liver, pancreas, lungs). Cyclosporine is also effective in the treatment of autoimmune diseases, active endogenous uveitis of a noninfectious etiology, Behçet uveitis (particularly in recurrent attacks), severe form of atopic dermatitis, steroid-dependent and steroid-resistant forms of nephrotic syndrome, severe forms of psoriasis, severe forms of rheumatoid arthritis.
Precautions for Neoral
Cyclosporine is contraindicated in the following cases: malignant tumors, precancerous conditions of the skin, hypersensitivity to active or auxiliary components, period of lactation, pediatric patients (up to one year).
Cyclosporine should be used with caution in case of varicella, kidney and liver failure, virus infections, hypertension, hyperkalemia, malabsorption syndromes.
Do not use cyclosporine in patients with impaired renal function, uncontrolled hypertension, infectious diseases, malignant neoplasms.
Simultaneous treatment with tacrolimus should be avoided.
Cyclosporine can lead to the development of various bacterial, fungal and viral infections (sometimes fatal). It is necessary to choose the appropriate therapeutic strategy for patients with long-term immunosuppression.
Neoral instructions for use
Typically, cyclosporine treatment scheme depends on the indications (it should be set individually, in accordance with a physician). The capsule must be swallowed whole.
Cyclosporine should be taken no later than 12 hours before the organ transplant operations at a dosage of 10-15 mg per 1 kg of body weight, divided into 2 doses. Patients should take the same doses after the operation (every day for a few weeks). The maintenance daily dose is 6.2 mg per 1 kg of body weight. If the drug is used in conjunction with other immunosuppressive agents and corticosteroids, then reduced dosages may be used.
Supportive treatment should be continued for six months. After that, the dose should be gradually reduced. As a rule, the total duration of Neoral therapy is one year (treatment may last longer in some cases).
Treatment of endogenous uveitis and nephrotic syndrome: the initial daily dose is of 5 mg per 1 kg. When monotherapy does not bring the expected result, it is possible to combine cyclosporine with small doses of glucocorticoids.
Treatment of rheumatoid arthritis: the daily dose is 3 mg per 1 kg of body weight divided into 2 doses (during the first 6 weeks of therapy). The total duration of therapy should not exceed twelve weeks.
Treatment of psoriasis and atopic dermatitis: the daily dose ranges from 2.5 to 5 mg per kg (divided into 2 doses).
Neoral interactions with other drugs
Cyclosporine increases the risk of side effects when used with nonsteroidal anti-inflammatory drugs.
The risk of nephrotoxicity is higher in combination therapy with amphotericin B, aminoglycosides, colchicine, trimethoprim, ciprofloxacin, melphalan.
Potassium supplements may increase the risk of hyperkalemia.
Lovastatin increases the risk of muscle pain and weakness.
Neoral side effects
Many side effects associated with cyclosporine depend on the dose. The frequency and severity of side effects may vary. Side effects are more frequent in patients who have undergone transplantation.
Cyclosporine can cause lymphoma and malignant skin diseases. In some cases, cyclosporine can cause anaphylactic reactions in the form of acute respiratory distress syndrome, skin rash, shock, bronchospasm, tachycardia, lower blood pressure.
Other disorders include: nephropathy, weight gain, gingival hyperplasia, tremor, hyperkalemia, headache, hypomagnesemia, paresthesia, pancreatitis, stomach pain, arrhythmias, hyperlipidemia, allergic reactions, nausea, loss of appetite, vomiting, diarrhea, weakness, hepatotoxicity, thrombocytopenia, edema, myasthenia gravis, muscle spasms and myopathy, encephalopathy, anemia, dysmenorrhea, amenorrhea.