Trecator-SC (ethionamide) Coupons, Discounts & Cost
Trecator-SC (ethionamide) is a synthetic antituberculous drug. One way to save money on the Trecator-SC retail cost regardless of income and insurance status is to use Trecator-SC coupons or discount cards from RXCoupons. Use this Ethionamide coupon at this online pharmacy and receive up to 75% off the sale price.
Trecator-SC description
Trecator-SC (ethionamide) is a synthetic antituberculous drug. The active substance blocks the growth and reproduction of Mycobacterium tuberculosis bacteria.
Ethionamide is rapidly absorbed from the digestive tract. The drug can pass through the placental barrier. Less than 1% is excreted unchanged in the urine.
Trecator-SC indications: tuberculosis of the lungs (in case of intolerance or inefficiency of other anti-tuberculosis drugs).
Trecator-SC dosage and administration
It is necessary to monitor the activity of hepatic transaminases every 2-4 weeks of treatment.
Patients should avoid simultaneous administration of drugs that have hepatotoxic effects.
The average daily dose of the drug for adults is 0.5-1 g 2-3 times per day. This drug should be taken with food.
The initial daily dose is 250 mg. After 5 days, in case of good tolerability, the dose can be increased to 500 mg, and then up to 0.75-1 g. Children should use doses of 20-40 mg/kg/day.
The maximum daily dose is 1 g. Patients older than 60 years of age with a body weight of less than 50 kg should take 250 mg twice a day. 12-24 months is the minimum duration of treatment.
Trecator-SC side effects
Common side effects may include allergic reactions, disorders of the central nervous system (insomnia, depression). There may be other side effects: loss of appetite, weight loss, nausea, vomiting, stomach pain, flatulence, diarrhea. It is assumed that these side effects are associated with the violation of vitamin balance in patients.
Digestive system: anorexia, stomatitis, nausea, vomiting, pain in the epigastric area, diarrhea, flatulence, hepatotoxicity up to hepatitis.
CNS: peripheral neuritis, optic neuritis, mental disorders, headache, paresthesia, convulsions, drowsiness or insomnia, weakness, depression, hallucinations, agitation, psychosis.
Skin: rash, hives, exfoliative dermatitis.
Cardiovascular system: tachycardia, orthostatic hypotension, thrombocytopenia.
Other disorders: gynecomastia, dysmenorrhea, impotence, hypothyroidism, weight loss, arthralgia, photosensitivity.
Overdose symptoms: hepatitis or jaundice, peripheral neuritis, mental disorders, hypothyroidism, hypoglycemia, skin rash and optic neuritis.
Trecator-SC contraindications
Trecator-SC has a small number of contraindications: acute gastritis, peptic ulcer and duodenal ulcer, ulcerative colitis, cirrhosis and other liver diseases, chronic alcoholism, renal insufficiency, pregnancy, hypersensitivity to ethionamide, pyrazinamide, nicotinic acid and other similar drugs. Trecator-SC is not used in patients under 14 years of age.
Use with caution in case of diabetes mellitus, epilepsy, liver diseases, depression and other mental illnesses.
Interaction with other drugs
This drug is used only in combination with other anti-TB drugs. It is not recommended to combine ethionamide with prothionamide.
Ethionamide can enhance some side effects (in particular convulsions) of other antituberculosis drugs.
Liver function should be monitored regularly if you combine Trecator-SC with pyrazinamide.
If the patient has certain nervous system disorders or mental disorders, then ethionamide should not be combined with cycloserine. Cycloserine may cause neurotoxic side effects (especially in patients who have neurological or psychiatric disorders).
What should I know about Trecator-SC special instructions?
It is necessary to avoid using drugs that have hepatotoxic effects.
It is necessary to monitor the activity of liver transaminases every 2-4 weeks of treatment.
Ethionamide should be used in combination with other anti-tuberculosis drugs. It is not recommended to use ethionamide in combination with prothionamide.
Pyridoxine should be prescribed to prevent the risk of peripheral neuritis.
Keep this drug out of the reach of children, in a dry, protected from light place, at a temperature of no higher than 25° C.