Vepesid (etoposide) Coupons, Discounts & Cost
Vepesid is a drug belonging to the class of cytostatics. One way to save money on the Vepesid retail cost regardless of income and insurance status is to use Vepesid coupons or discount cards from RXCoupons. Use this Etoposide coupon at this online pharmacy and receive up to 75% off the sale price.
General information about Vepesid
Vepesid is a drug belonging to the class of cytostatics. The active ingredient is etoposide - a semisynthetic derivative of podophyllotoxin.
Vepesid is an antitumor agent. It is used to treat germinogenic tumors (testicular tumors, choriocarcinoma), ovarian cancer, small cell and non-small cell lung cancer, Hodgkin's lymphoma, non-Hodgkin's lymphoma, Ewing's sarcoma, Kaposi's sarcoma, stomach cancer (as monotherapy and combined therapy), neuroblastoma, breast cancer (with metastases in liver, pleura), acute non-lymphoblastic leukemia, mesothelioma.
How to use Vepesid
The dose of etoposide is chosen individually, depending on the stage of the disease, the scheme of antitumor therapy, etc.
The following doses are used: 1) 100 mg/m 2/day - from 1 to 5 days. Repeat the course every 3-4 weeks. 2) 100-125 mg/m 2 every other day (days 1, 3, 5). Repeat the course after the first three weeks. 3) Tablets: 50 mg/m 2 daily for 21 days. Repeat the course every 4 weeks.
Side effects of Vepesid
Vepesid therapy can cause nausea, vomiting (these symptoms are stopped by using anti-emetic drugs). Also, some side effects may include anorexia, diarrhea, stomatitis, fever, tachycardia, bronchospasm, dyspnea.
This drug is characterized by hematological toxicity. The therapy may also cause hair loss and alopecia, peripheral neuropathy, drowsiness, fatigue, rash.
Hematopoietic system: leukopenia, anemia, thrombocytopenia.
Metabolism: hyperuricemia, metabolic acidosis (when using high doses).
Digestive system: nausea, vomiting, abdominal pain; rarely - anorexia, mucositis, diarrhea, stomatitis, hyperbilirubinemia. Nausea and vomiting are the most common side effects. Antiemetics are prescribed to control these side effects.
Central nervous system and peripheral nervous system: drowsiness, fatigue.
Cardiovascular system: tachycardia, arterial hypotension.
Reproductive system: azoospermia, amenorrhea.
Allergic reactions: chills, fever, bronchospasm, tachycardia, dyspnea, swelling of the face or tongue, excessive sweating, cyanosis, laryngospasm, back pain, loss of consciousness. These reactions were usually observed immediately after the administration of etoposide.
Dermatological reactions: alopecia, rash, hives, itching.
Other toxic effects: peripheral neurotoxicity, fever, pigmentation, dysphagia, metabolic acidosis, numbness or tingling in the fingers and toes, weakness, muscle cramps, hyperuricemia, phlebitis (pain at the injection site).
Vepesid safety information
You should avoid taking Vepesid in case of violations of the liver and kidneys, pregnancy, hypersensitivity to etoposide. This drug is not used in children under 2 years of age.
Etoposide is contraindicated in pregnant women. Patients using Vepesid should stop breastfeeding. Etoposide has teratogenic and embryotoxic effects.
What you should know before using Vepesid
Treatment should be performed by an experienced physician.
Hypersensitivity reactions may occur after the first administration of the drug. It is necessary to stop using this drug and begin treatment with corticosteroids or antihistamines in case of the following reactions: chills, fever, tachycardia, bronchospasm.
The drug is used with caution in patients after radiation or chemotherapy, as well as those with myelosuppression, chicken pox, herpes zoster, infectious lesions of the mucous membranes, heart rhythm disturbances, impaired liver function, diseases of the nervous system (epilepsy), chronic alcoholism. Use with caution in patients with hypoalbuminemia (high risk of toxic effects of etoposide).
It is necessary to consult a doctor before using Vepesid in children older than 2 years.
Vaccination should be avoided during Vepesid therapy.
Vepesid should be used with extreme caution with cisplatin.
High doses of cyclosporine can reduce the clearance of etoposide.
Vepesid should be stored in a dry place, protected from light, at a temperature not exceeding 25° C.