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Mysoline (primidone) Coupons, Discounts & Cost

Mysoline (primidone) is an antiepileptic drug with mild hypnotic effect. One way to save money on the Mysoline retail cost regardless of income and insurance status is to use Mysoline coupons or discount cards from RXCoupons. Use this Primidone coupon at this online pharmacy and receive up to 75% off the sale price.

How does Mysoline work in your body?

Mysoline (primidone) is an antiepileptic drug with mild hypnotic effect. The drug helps reduce the excitability of neurons in the epileptic focus.

Mysoline indications: epilepsy (seizures, focal seizures, myoclonic seizures and akinetic seizures, complex partial seizures). Mysoline is not effective for other forms of epilepsy (non-convulsive status epilepticus, epilepsy with polymorphic seizures, etc.).

Primidone is almost completely absorbed from the gastrointestinal tract. The maximum concentration can be reached within 3 hours. The drug is excreted by the kidneys.

What are the contraindications for Mysoline?

Mysoline (primidone) is unacceptable in the following cases:

  • Hypersensitivity;
  • Liver or kidney failure;
  • Anemia;
  • Leukopenia;
  • Pregnancy;
  • Lactation.

Primidone should be used with caution in children, elderly patients, debilitated patients, and people with kidney dysfunction, hepatic insufficiency or respiratory dysfunction.

What are the side effects of Mysoline?

Common side effects: lethargy, apathy, anxiety, blurred vision, headache, dizziness, nausea, vomiting, nystagmus, ataxia, arthralgia, psychotic reactions, megaloblastic anemia, rash, systemic lupus erythematosus.

Nervous system: drowsiness, dizziness, headache, ataxia, apathy, anxiety, psychotic reactions, nystagmus (rare).

Digestive system: nausea, vomiting.

Hematopoiesis: megaloblastic anemia, leukopenia.

Other: folic acid deficiency, lupus-like syndrome, arthralgia, drug dependence (with long-term use), allergic reactions.

Overdose symptoms: dizziness, nausea, ataxia, CNS depression.

What is the usual dosage of Mysoline?

The therapy should be started with 125 mg 1 time per day (in the evening). Patients should increase the dose up to 500 mg per day every three days. The maximum daily dose is 1.5 g for adults and 1 g for children.

Mysoline interactions with other drugs

Mysoline should be used with caution with carbamazepine, diphenylhydantoin, and other anticonvulsants.

Primidone enhances the effect of hypnotic drugs, sulfonylurea derivatives, cyclophosphamide, methotrexate.

The drug accelerates metabolism and reduces the effect of paracetamol, indirect anticoagulants, tricyclic antidepressants, chloramphenicol, cyclosporine, doxycycline, levothyroxine, metronidazole, digitalis glycosides (digoxin to a lesser extent), disopyramide, mexiletine, quinidine, fenoprofen, aminophylline, caffeine, theophylline, vitamin D.

Mysoline may lead to CNS depression when combined with alcohol.

Amphetamine slows the gastrointestinal absorption of the drug.

Mysoline enhances the toxic effect of drugs for general anesthesia (enflurane, halothane, methoxyflurane).

Primidone reduces the absorption of griseofulvin (reduces the antifungal activity of griseofulvin).

Guanethidine, haloperidol, maprotiline, molindone, loxapine, phenothiazines, and thioxanthenes may lead to central nervous system depression.

When used in large doses, leucovorin (folinic acid) reduces the effect of primidone.

Methylphenidate inhibits the metabolism of primidone and increases its concentration in the blood (this can lead to toxic effects).

Hormones released by the posterior pituitary increase the risk of arrhythmias and coronary insufficiency.

Valproic acid may increase the concentration and toxicity of primidone.

Other antiepileptic drugs reduce the effectiveness of primidone.

Primidone may reduce the effectiveness of oral contraceptives. It is necessary to use other methods of contraception during treatment.

Primidone may reduce the effectiveness of paracetamol.

Primidone may increase the risk of hepatotoxicity in patients who consume alcohol on a regular basis.

What are special instructions for Mysoline?

Mysoline can be used as a part of complex anticonvulsant therapy. The dose should be reduced gradually (at the end of therapy).

Patients should stop taking the drug and start treatment with folic acid and/or vitamin B12 in the case of megaloblastic anemia.

The drug may reduce reaction times (be careful when driving).

Storage conditions

In dry place, at room temperature.

Medical Conditions

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